Mirtazapine is a medication that has been used for years to treat depression in humans. However, it has also been found to be effective in stimulating appetite and relieving nausea in pets. While the oral form of mirtazapine is commonly prescribed by veterinarians, the transdermal form has recently become a popular alternative due to its ease of use and effectiveness.

In this article, we will discuss what mirtazapine transdermal is, how it works, its benefits and risks, and how it can help your furry friend regain their appetite and overcome nausea.

What is Mirtazapine Transdermal?

Mirtazapine transdermal is a medication that is applied topically to the skin of your pet. It is formulated with mirtazapine, a drug that is classified as a tetracyclic antidepressant. The transdermal form of the medication is absorbed through the skin and enters the bloodstream, providing a sustained-release of the drug over time.

How Does Mirtazapine Transdermal Work?

Mirtazapine works by increasing the level of serotonin and norepinephrine in the brain, which helps to regulate mood and appetite. In pets, it is primarily used to stimulate appetite and reduce nausea.

When mirtazapine is applied topically to the skin, it is absorbed into the bloodstream and reaches the brain. It then binds to specific receptors in the brain that control appetite and nausea, increasing the release of certain hormones that stimulate hunger and reduce feelings of nausea.

Benefits of Mirtazapine Transdermal for Pets

Mirtazapine transdermal has several benefits for pets, including:

1. Appetite Stimulation:

One of the primary uses of mirtazapine transdermal is to stimulate appetite in pets. It can be particularly helpful in pets that have lost their appetite due to illness or medication.

2. Nausea Relief:

Mirtazapine transdermal can also be effective in reducing nausea in pets. This is particularly useful for pets that are undergoing chemotherapy or other treatments that can cause nausea.

3. Easy to Use:

Mirtazapine transdermal is easy to apply and can be administered at home. This can save pet owners time and money compared to taking their pet to the veterinarian for injections or oral medication.

4. Fewer Side Effects:

Mirtazapine transdermal has fewer side effects compared to oral medication, which can cause drowsiness, dry mouth, and constipation.

Risks of Mirtazapine Transdermal for Pets

While mirtazapine transdermal is generally safe for pets, there are some risks to consider, including:

1. Overdose:

Overdosing on mirtazapine can be dangerous for pets and can cause symptoms such as vomiting, diarrhea, lethargy, and even seizures. It is important to follow the dosage instructions carefully and to contact your veterinarian immediately if you suspect an overdose.

2. Allergic Reactions:

Some pets may be allergic to mirtazapine, which can cause symptoms such as itching, swelling, and difficulty breathing. If your pet experiences any of these symptoms, stop using the medication immediately and contact your veterinarian.

3. Interactions with Other Medications:

Mirtazapine can interact with other medications, including antidepressants, sedatives, and pain relievers. It is important to tell your veterinarian about all medications your pet is taking before administering mirtazapine transdermal.

How to Administer Mirtazapine Transdermal

Mirtazapine transdermal is easy to administer at home. The medication comes in a patch that should be applied to a hairless area of your pet’s skin, such as the inner ear flap. The patch should be changed every three days to ensure a sustained-release of the medication.

Before applying the patch, clean the area with alcohol and make sure it is dry. Then, peel the backing off the patch and press it firmly onto the skin. Make sure the patch is secured and does not fall off.

It is important to follow the dosage instructions provided by your veterinarian carefully. The recommended dosage for mirtazapine transdermal varies depending on the size and condition of your pet. Your veterinarian will determine the appropriate dosage and frequency of administration for your pet.


Mirtazapine transdermal is an effective medication for stimulating appetite and reducing nausea in pets. It is easy to administer at home and has fewer side effects compared to oral medication. However, it is important to follow the dosage instructions carefully and to monitor your pet for any adverse reactions.

If you suspect an overdose or an allergic reaction, contact your veterinarian immediately. With proper administration and monitoring, mirtazapine transdermal can help your furry friend regain their appetite and overcome nausea.